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- W2370793257 abstract "Objective To study the reinforcement of nimodipine to the therapy of acyclovir(ACV)-mediated HSV-TK gene to induce glioma cell to death and the mechanisms of the bystander effect in the procedure.Methods A recombinant retroviral vector containing a fusion gene encoding both HSV-TK and hygromycin phosphotransferase was constructed.It transfected both BT325 and SCW glioma cells successfully.In vitro cytotoxic effect of ACV combined with nimodipine on the tk gene therapy was observed.Results The trans-tk cells were more sensitivity to the treatment with ACV plus nimodipine than ACV alone and low concentration of nimodipine significantly enhanced the “bystander effect”.Conclusions Nimodipine can reinforce the tk suicide gene therapy of glioma in vitro.It contributes to the establishment of the experimental basis of nimodipine combine with tk gene therapy for brain tumors." @default.
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- W2370793257 date "2003-01-01" @default.
- W2370793257 modified "2023-09-23" @default.
- W2370793257 title "Reinforcement of nimodipine to the TK suicide gene therapy of glioma" @default.
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