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- W2370794097 abstract "Objective:To investigate the effect of Chinese medicine Recipe by external application for detecting the rat tumor growth inhibition,then explore the anti-tumor mechanism of action.Methods:Fifty mice were divided into 5groups,the normal group,cyclophosphamide group,high dose of plucking tumor mastic group,medium dose of plucking tumor mastic group,low dose of plucking tumor mastic group.Three groups of treatment by plucking tumor mastic(high dose,medium dose,low dose)were given 0.5ml dose respectively by smearing skin under right armpit for 14 days and cyclophosphamide group was given cyclophosphamide for 7 days,in order to observe continuously the condition of rat tumor growth inhibition by treatment of plucking tumor mastic.From tumor tissue in rat,cell cycle and number of apoptotic cells were detected by flow cytometer,and expression of caspase-3 was determined by reverse transcription polymerase chain reaction method.Results:In G422 cell of rat model,except for cyclophosphamide group,high dose of plucking tumor mastic group was obviously growth inhibition when compared with other groups,which its rate of growth inhibition was 31.28%.According result of flow cytometer,high dose of plucking tumor mastic group made obviously tumor tissue cells stop stage of G0/G1(P0.05),and cells in stage of S decrease(P0.05).No significant difference between the normal group and the other groups,but the rate of apoptotic cells in high dose of plucking tumor mastic group was (23.6±4.35)% from apoptotic cells analysis,which was obviously higher than the normal group(8.86±1.23)%.With dose gradually increasing,expression of caspase-3 of high dose of plucking tumor mastic group was significantly superior to other groups[(23.45±2.31)vs(7.24±0.36),P0.01].Conclusion:Chinese medicine Recipe could inhibit the tumor growth on rat's model.The anti-tumor mechanism of action was about related to inhibit the composition of tumor cell DNA,stoppage cycle,induce the apoptosis of G422 cells and up-regulate the expression of caspase-3." @default.
- W2370794097 created "2016-06-24" @default.
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- W2370794097 date "2010-01-01" @default.
- W2370794097 modified "2023-09-25" @default.
- W2370794097 title "Effect of Chinese Medicine Recipe on Anti-tumor of Small Rat Glioblastoma and the Mechanism of Action" @default.
- W2370794097 hasPublicationYear "2010" @default.
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