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- W2370798436 abstract "Objective To investigate the effects of lysophosphatidic acid on the production of ET, NO and TGFβ1 in cardiac fibroblasts (CFs) in neonate rats. Methods CFs were isolated by trypsin digestion method, the changes of ET, NO and TGFβ1 production from CFs were examined by radio immunoassay, nitrate reductase-dependent assay and by enzyme linked immunosorbent assay(ELISA), respectively. Results LPA(1×10 -9-1×10 -6mol/L)decreased ET and TGFβ1 synthesis in a concentration-dependent manner( P0.05), but showed no significant changes to NO production(P0.05). Conclusion These results showed that LPA can decrease the production of ET, TGFβ1 and influence the balance of these factors. LPA may inhibit myocardial fibrosis by modulating these cytokines." @default.
- W2370798436 created "2016-06-24" @default.
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- W2370798436 date "2006-01-01" @default.
- W2370798436 modified "2023-09-22" @default.
- W2370798436 title "Effects of Lysophosphatidic Acid on the Production of ET, NO and TGF β_1 in Myocardial Fibroblasts in Neonate Rats" @default.
- W2370798436 hasPublicationYear "2006" @default.
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