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- W2370798908 abstract "Objective To investigate whether 99mTc-HL91 hypoxia imaging could be used to monitor reoxygenation of tumor after radiation therapy,and to analyze the relationship between 99mTc-HL91 hypoxia imaging and the expression of HIF-1a(hypoxia induce factor-1a).Methods H22 tumor-bearing mice were randomly divided into control group and experimental group,and the latter was further divided into 1 d,3 d,5 d subgroups according to the different time after radiotherapy.The experimental group accepted ~(60)Co radiotherapy at a single dose of 15 Gy.All groups underwent SPECT plane imaging two hours after injected 99mTc-HL91 hypoxia imaging agent.ROIs were drawn around the tumor and contralateral muscles in planar images to calculate the T/NT of imaging in all mice.The mice were killed immediately after image acquisition,then the tumors were excised,weighted.Radioactivity was measured,and DUR(differential uptake ratio)was computed for quantitation of the tracer uptake.Immunohistochemical analyses of HIF-1a expression were also performed in excised tumor.Finally the relationship between T/NT(T:tumor;NT:non tumor),DUR values in different time groups and HIF-1a expression was analyzed.Results Compared with the control group,DUR and T/NT values decreased first and then decreased with the time of radiotherapy,and the quantities of HIF-1a positive cells also showed similar expression that decreased at first and then decreased.Significant positive correlation was found between DUR,T/NT values in diffferent time groups respectively and HIF-1a expression(r=0.75,0.86,both P0.05).Conclusion 99mTc-HL91 hypoxia imaging and HIF-1a expression can be used to determine reoxygenation of tumor after radiation therapy,and positive correlation exists between them." @default.
- W2370798908 created "2016-06-24" @default.
- W2370798908 creator A5058579214 @default.
- W2370798908 date "2009-01-01" @default.
- W2370798908 modified "2023-09-23" @default.
- W2370798908 title "~(99m)Tc-HL91 hypoxia imaging to monitor reoxygenation states of H_(22) liver tumor-bearing KM mice after radiation therapy" @default.
- W2370798908 hasPublicationYear "2009" @default.
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