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- W2370801341 abstract "Objective By observing the changes in expression of soluble intercellular adhesion molecule-1(sICAM-1) and soluble CD44v6(sCD44v6) in peritoneal lavage fluid in laparoscopic and open surgery,to investigate the possible effects of laparoscopically assisted radical gastrectomy on peritoneal metastasis.Methods In accordance with the Japanese Gastric Cancer Treatment Guidelines(13th edition),radical gastrectomy was performed in 26 patients with gastric cancer by laparoscopic surgery and 20 patients by open laparotomy.Peritoneal lavage fluid was collected at the beginning and the end of operation.The concentrations of both sICAM-1 and sCD44v6 were detected by enzyme linked immunosorbent assay(ELISA).Results Before the operation,the sICAM-1 levels were higher in those patients with poorly differentiated gastric cancer compared with that in those patients with well or moderately differentiated tumors(P0.05).However,the sCD44v6 levels showed no relation to the degree of differentiation.The concentrations of sICAM-1 and sCD44v6 in peritoneal lavage at the beginning of operation were closely correlated to tumor node metastasis(TNM) staging(P0.05).The levels of both sICAM-1 and sCD44v6 in peritoneal lavage increased obviously as the operation time went on in both groups of patients(P0.05),and no difference was found in the changes in sICAM-1 and sCD44v6 levels between the two groups(P0.05).Conclusions Compared with open surgery,laparoscopically assisted radical gastrectomy does not increase the expression of sICAM-1 and sCD44v6 in peritoneal lavage,therefore it seems unlikely that laparoscopic gastrectomy may facilitate the peritoneal metastasis by enhancing the expression of adhesion molecules." @default.
- W2370801341 created "2016-06-24" @default.
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- W2370801341 date "2009-01-01" @default.
- W2370801341 modified "2023-09-23" @default.
- W2370801341 title "Effects and significance of laparoscopically assisted radical gastrectomy on expression of soluble ICAM-1 and CD44v6 in peritoneal lavage" @default.
- W2370801341 hasPublicationYear "2009" @default.
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