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- W2370805640 abstract "Objective Metaplastic breast carcinoma(MBC) encompasses a heterogeneous group of tumors.Based upon the microarray of MBCs,these tumours showed features of basal-like carcinoma and myoepithelial differentiation.However,MBCs entity still remained unclear,so we performed a systematic research to explicit MBCs for further.Methods A panel of ER,PR,HER2,CK5/6,CK14,P63 and EGFR were prepared for detection of MBCs,and fluorescence in situ hybridization for HER2 gene amplification and ultrastructure observation were also performed.Sensitive between CK5/6 and others antibody in diagnosis and survival analysis were also carry out.Results ER,PR and HER2 were negative.CK5/6(12/12),CK14(9/12),EGFR(10/12) and P63(8/12) were positive.FISH for HER2 displayed no amplification(Ratio1.8).Ultrastructure showed tonofibrils,thin filament and dense body in the cytoplasm.Significant statistically differences were showed between groups(P=0.000) of score of CK5/6,CK14,P63 and EGFR.Significant statistically differences were also detected between age and lymph node involvement and survival(P=0.004).Conclusions MBCs may be actually basal-like carcinomas.In the diagnosis of MBCs,CK5/6,CK14,P63 and EGFR may be effective and CK5/6 may be more sensitive than CK14 and P63.Survival of MBCs may be associated with age and lymph node involvement." @default.
- W2370805640 created "2016-06-24" @default.
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- W2370805640 date "2010-01-01" @default.
- W2370805640 modified "2023-09-28" @default.
- W2370805640 title "Clinicopathological analysis of 12 patients with metaplastic breast carcinoma" @default.
- W2370805640 hasPublicationYear "2010" @default.
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