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- W2370809920 abstract "Objective To study the effect of endotoxin on brain cell apoptotic in aging rats.Methods Endotoxin and TNF-α content of plasma were determined in normal and after endotoxin infection of 24 months old and 6 month old rats.Effect of endotoxin and TNF-α on free Ca2+ in brain cells were observed in vitro,and apoptosis of brain cells were examined by FCM.Results The level of endotoxin in plasma were much higher in 24 months old rats than those of 6 months old rats in both normal and after endotoxin injection groups,but TNF-α was increased significantly only after endotoxin injection.TNF-α was elevated significantly free Ca2+in brain cells,and after endotoxin injection via portal vein apoptosis of brain cells were developed.Conclusions Increased plasma endotoxin toxin and TNF-α in 24 months old rats contributed to elevation of Ca2+ in brain cells and apoptosis,and the mechanism might involves changes of brain microecological environment induced by altered cytokine." @default.
- W2370809920 created "2016-06-24" @default.
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- W2370809920 date "2012-01-01" @default.
- W2370809920 modified "2023-09-24" @default.
- W2370809920 title "Effect of endotoxin on brain cell apoptotic in aging rats" @default.
- W2370809920 hasPublicationYear "2012" @default.
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