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- W2370827206 abstract "OBJECTIVE To investigate the anti-angiogenesis and tumor inhibitory effects of recombinant human endostatin(rhES) combined with vinorelbine-cisplatin chemotherapy(NP regimen) on xenograft tumors in nude mice of human breast carcinoma cell MDA-MB-435S.METHODS Forty xenograft nude mice were randomized into 4 groups: NP group(vinorelbine and cisplatin),rhES group(rhES),rhES+NP group(combined treatment as above-mentioned),and control group(normal saline).Inhibitory rate of xenograft and tumor growth curve was calculated and plotted.MVD,VEGF,HIF-1α and P53 were measured by immunohistochemistry.RESULTS Tumor inhibition rate of the rhES+NP group was 64.63%,but that of the NP group was 35.47%.Compared with the other 3 groups,MVD of the rhES+NP group significantly reduced,the difference was statistically significant(P0.05).HIF-1α,VEGF and P53 of the rhES+NP group was significantly lower than of the control group and the NP group,the difference was statistically significant(P0.05).CONCLUSION Experiments show that rhES combined with NP regimen can effectively control the tumor growth and decrease tumor MVD in nude mice,which may down-regulated the expression of VEGF and HIF-1α.The mechanism of rhES on P53 needs further study." @default.
- W2370827206 created "2016-06-24" @default.
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- W2370827206 date "2011-01-01" @default.
- W2370827206 modified "2023-09-26" @default.
- W2370827206 title "Recombinant Human Endostatin Combined with Vinorelbine-cisplatin Chemotherapy in Treatment of Human Breast Cancer Xenograft in Nude Mice" @default.
- W2370827206 hasPublicationYear "2011" @default.
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