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- W2370831471 abstract "A randomized study to compare clinical pharmacology of three methods of complexsteriodal contraceptives was carried out in Chinese women from 1988 through 1989. These 3 contraceptivepreparations contain desogestrel (DG) (DG 0.15 mg/EE 0.03 mg). Levonorgestrel(LNG) (LNG 0.25mg/EE 0.05 mg) respectively, and the first 2 were given via intravaginal route, while the last orally. Thenumber of volunteers recuited for the 3 drugs groups was 34.66 and 32. Using the statistical life table calculation, the cumulative continuation rates at the end of one year for the 3 groups were 79.5%, 84.9%and 90.7%. The incidence of side-effect in the LNC (Vaginal) group was less vaginal bleeding than theLNG (oral) group(p0.05). The influence of three contraceptives on liver function and lipid metabolismwas as follows: the mean value of triglyceride(TG) in DG group was significantly higher than that of LNGgroup(p0.001), while the other indices or the liver function tests showed no significant change from thenormal values. As to the inhibition on ovulation, the ovulation rates of the 3 groups were 6/11, 12/15, 1/11 women respectively, indicating significant suppression on ovulation in the DG vaginal and LNG oralgroups, the oral group significantly different from the other group. The results thus showed that oral ad-ministration of contraceptive induced contraception through its inhibition on ovulation, while vaginal routeof such medications induced contraception through their influence on the cervical mucus and endometriaresulting in suppression of pregnancy. This clinical trial indicates that vaginal administration of complexsteriodal contraceptives may produce satisfactory antifertile effect and therefore can be a good route ofmedicatiion." @default.
- W2370831471 created "2016-06-24" @default.
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- W2370831471 date "1993-01-01" @default.
- W2370831471 modified "2023-09-26" @default.
- W2370831471 title "STUDIES ON CLINICAL PHARMACOLOGY OF INTRAVAGINAL ADMINISTRATION OF COMPLEX STERIODAL CONTRACEPTIVES" @default.
- W2370831471 hasPublicationYear "1993" @default.
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