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- W2370846564 abstract "Objectives:To study the effects of polymorphisms of eNOS at G894T and 4B/4A loci on incidence and the sports hypoxia acclimation to Acute Mountain Sickness(AMS).Methods:Phase 1:61 students,all male Chinese Han origin lowlanders,were involved in a 6h acute exposure to 4800m altitude-equivalent.Within 30 min of arriving at altitude,volunteers exercised at constant work rate for 20min on a cycle ergometer(70r/min),then rested for the remainder of the 6h altitude exposure.Incidence and severity of AMS symptoms were determined using the LLS.Phase 2:After 1wk of rest,48 volunteers completed an exercise performance testing in a 3wk period of intermittent altitude exposures(IAE)(2h/d,4d/wk)which was undertaken in 2500m,3500m and 4800m,respectively.Restore 1wk,repeat Phase 1.Incidence and severity of AMS symptoms were determined using the LLS.PCR-RFLP was used to determine the genotypes and alleles frequencies of eNOS at G894T and 4B/4A loci.Results:In Phase 1,49.2% individuals satisfied the diagnostic criteria for AMS.No significant differences of AMS incidence were detected in different genotypes and alleles at G894T loci,while AMS incidence in 4A allele carriers was remarkably higher than that in 4B carriers.Before and after exercising in hypoxia,the frequency distribution of AMS scores in subjects was significant different.60.4% volunteers won better hypoxia tolerance and 4A allele carriers had better hypoxia acclimation to AMS.Conclusions:Training in IAE is remarkable effective for the hypoxia acclimation to AMS.Allele 4A is one of the genetic marks for the incidence and the hypoxia acclimation to AMS." @default.
- W2370846564 created "2016-06-24" @default.
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- W2370846564 date "2010-01-01" @default.
- W2370846564 modified "2023-09-24" @default.
- W2370846564 title "Research Related to the Effects of Polymorphisms of eNOS on the Sports Hypoxia Acclimatization to Acute Mountain Sickness" @default.
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