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- W2370875215 abstract "Objective To evaluate the effect of dropping androgen on tear secretion,tear film stability by observing the changes of ocular surface,tear film and the histopathologyical changes of conjunctiva and lacrimal gland in castrated male rabbits.Methods Eighteen adult male rabbits were divided randomly into normal group,dry eye group and treated group.Their testicel and parastata cirsoides were exsected to make dry eye model in the last two groups.The rabbits of treated group were given 3% testosterone on duplicate eyes.Schirmer test,tear film break-up time(BUT),rose bangle staining were performed on the eyes of each rabbit before and after experiment at 1 week,2 weeks,3 weeks,4 weeks,6 weeks,8 weeks and 12 weeks.The serum testosterone level was detected before and after experiment,and the histopathologyical changes of the conjunctiva and lacrimal gland were observeed by using lightscope.Results After 6 weeks of the experiment,the tear seceretion increased and the BUT extended in treatment group.There was a significance difference between dry eye group and treatmemt group(P0.01).Topical dropping androgen has no obvious effect on whole-length level of androgen(P0.05).Loss of the lympha cells was observed in conjunctiva and lacrimal gland in treatmemt group.Conclution The low testosterone level of castrated male rabbits is one of the chief reasons of dry eye.Treated locally with androgen has an effect on low level androgen dry eye,but it has no obvious effect on whole-length level of androgen." @default.
- W2370875215 created "2016-06-24" @default.
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- W2370875215 date "2008-01-01" @default.
- W2370875215 modified "2023-09-27" @default.
- W2370875215 title "Observe on changes of the tears secretion and tear film stability in castrated male rabbits xerophthalmia eye model and effects of local androgen therapy" @default.
- W2370875215 hasPublicationYear "2008" @default.
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