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- W2370876964 abstract "Innate immune initiates at recognition of broad classes of conserved microbial molecular structures known as pathogen-associated molecular patterns(PAMPs)by a diverse set of germ line-encoded receptors,termed pattern recognition receptors(PRRs)such as Toll-like receptors(TLRs).TLRs are one of the largest and best studied families of PRR.TLRs activate innate immunity pathway,regulate the secretion of cytokines such as TNF-α,ILs and IFN-α,and ultimately modulate the function of immunity system.Over ten TLRs have been discovered in human genome that may be the therapy targets for cancer,viral and bacterial infection,inflammation,autoimmunity and radiation injury.Several compounds targeting TLRs are now undergoing preclinical or clinical evaluation,including anti-tumor drugs,anti-virus drugs,anti-infection drugs and anti-radiation drugs.The structural feature of TLRs,the characteristics of their signaling pathways,and the development status of related compounds for therapeutic manipulation were summarized." @default.
- W2370876964 created "2016-06-24" @default.
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- W2370876964 date "2010-01-01" @default.
- W2370876964 modified "2023-09-23" @default.
- W2370876964 title "Development of Potential Therapeutics Targeting to Human Toll-like Receptor" @default.
- W2370876964 hasPublicationYear "2010" @default.
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