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- W2370878314 abstract "Objective:To develop a novel HPLC method for the analysis of 9-nitrocamptothecin(9-NC)in rat urine.Methods:The urine samples were separated on a C_(18)column after being diluted by methanol-acetonitrile(1 :1).The mobile phase consisted of acetonitrile and 1% triethylamine(pH 6.5)(45:55)at a flow rate of 1.0 mL ·min~(-1).The UV detector was set at 370 nm.The ratios of cumulative excretion in urine to the administered dose were determined at different time following intravenous administration of 3 mg·kg~(-1)9-NC solution or liposome to rats.Results:The linear calibration curves were obtained in the concentration range of 72-18000 ng·mL~(-1).The limit of quantification was 72 ng·mL~(-1).After intravenous administration of 9-NC solution or liposome,the ratios of cumulative excretion in urine to the administered dose were 5.9% and 7.6%,respectively.Conclusion:The method which was simple,practical and accurate was successfully applied to the study of cumulative excretion of 9 -NC into urine." @default.
- W2370878314 created "2016-06-24" @default.
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- W2370878314 date "2008-01-01" @default.
- W2370878314 modified "2023-09-27" @default.
- W2370878314 title "HPLC determination of the concentration of 9-nitrocamptothecin in rat urine" @default.
- W2370878314 hasPublicationYear "2008" @default.
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