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- W2370899530 abstract "Objective : To discuss the role of nitric oxide in the development of diabetes mellitus by observing the numerical changes of neuronal nitric oxide synthase immunoreactive (nNOS-ir) neurons in spinal cord of diabetic rats. Methods : Diabetic rats was induced by intraperitoneal administration of streptozotocin (STZ). The method of ABC immunocytoche-mistry was used to show the nNOS-ir neurons. Results : nNOS-ir neurons appeared in the central grey matter and the lateral nucleus of spinal cord. nNOS-ir neurons concentrated in the lateral nucleus, and the processes of neurons bunchily extended to the central grey matter. The quantitative analysis showed that the number of nNOS-ir neurons around the central grey matter and the lateral nucleus in spinal cord of diabetic rats was significantly increased in 7 and 12 weeks. Conclusion : The afferents from noxious stimuli increase in diabetic rats; the increase of nNOS-ir neurons maybe related to diabetic peripheral neuropathy like hyperalgesia." @default.
- W2370899530 created "2016-06-24" @default.
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- W2370899530 date "2003-01-01" @default.
- W2370899530 modified "2023-09-23" @default.
- W2370899530 title "Changes of neuronal nitric oxide synthase immunoreactive neurons in spinal cord of diabetic rats" @default.
- W2370899530 hasPublicationYear "2003" @default.
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