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- W2370927986 abstract "Objective To explore the relationship between methylation of p16 gene and the prognosis of multiple myeloma(MM).Methods Fifty-two patients with multiple myeloma were tested for methylation status of the first exon of p16 gene by restriction enzymeralated polymeras chain reaction(REP),and those with positive results were detemined for transcriptioin level of mRNA.The clinical data and prognostic factors of the 52 patients were analyzed.Results Twenty-eight(53.84%)cases of methylation of the first exon of p16 gene were observed,of which the negative rate of mRNA was 75%.The levels of factors adversely influencing the prognosis in the patients with methylation of the first exon of p/G gene were significantly higher than those in the patients without methylation.Conclusion The hypermethylation of p16 gene was related to the prognosis of multiple myeloma." @default.
- W2370927986 created "2016-06-24" @default.
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- W2370927986 date "2007-01-01" @default.
- W2370927986 modified "2023-09-25" @default.
- W2370927986 title "Relationship between Methylation of p16 Gene and Prognosis of Multiple Myeloma" @default.
- W2370927986 hasPublicationYear "2007" @default.
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