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- W2370941945 abstract "Objective:To analyze the incidence,clinical characteristics,diagnosis,treatment and prognosis of tuberculous infections following allogeneic hematopoietic stem cell transplantation(allo-HSCT).Method:Six cases with tuberculous infection were confirmed among 258 recipients underwent allo-HSCT who were admitted to our institution.Their clinical data were retrospectively collected and analyzed..Result:Tuberculous infections occurred in six patients of 258 cases following allo-HSCT.The overall incidence was 2.32%.The incidences were not significantly different.among haploid,unrelated and sibling transplantation.The types of tuberculous infection were various.There were one case of tuberculous meningitis,one case of tuberculous pleurisy,one case of tuberculous peritonitis,two cases of tuberculous lymphadenitis and one case of pulmonary tuberculosis.The median duration of tuberculous presentation after transplantation was 83 days(range 28-138 d).The median time from symptoms onset to diagnosis was 24 days(range 11-32 d).The first and major clinical manifestation were fever with no reasons for long time complicated with tuberculous toxic symptoms.Five cases were diagnosed with special clinical symptom,positively laboratory examinations and imaging studies,exclusion of other opportunistic infections and clinical response to antituberculosis drugs.One patient was diagnosed with positive acid-fast bacilli in sputum smears.Five patients were treated with combination of three or four standard antituberculosis drugs(INF+RFP+PZA and/or EMB).Among these five patients,two patients received full time therapy for seven months and survived,three gained clinical response to antituberculosis drugs but gave up treatments because of economical reason.One patient died before diagnosis.Conclusion:The cellular immunity of HSCT recipients is extremely disrupted thus these patients have high incidence of opportunistic infections.It should be noticed that tuberculous infections can occur in the early stage of HSCT,thus need early diagnosis and treatments.Diagnosis of tuberculous infections depends on combination of approached because of no special clinical symptom and low percent of positive laboratory examinations.The types and clinical symptoms of tuberculosis infections are diverse.The patients who receive standard combined treatments have good response to therapy.It should be paid attention to screening tuberculous infections before transplantation and preventing tuberculous infections post transplantation in high risk group." @default.
- W2370941945 created "2016-06-24" @default.
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- W2370941945 date "2011-01-01" @default.
- W2370941945 modified "2023-09-23" @default.
- W2370941945 title "Tuberculous infections following allogeneic hematopoietic stem cell transplantation" @default.
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