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- W2370946598 abstract "Objective To explore the changes of levels of serum soluble intercellural adhesion molecule-1(sICAM-1),the diurnal variation of leukocyte CD18 expression in peripheral blood and the concentration of serum B-type natriuretic peptide(BNP) in the patients with chronic congestive heart failure(CHF),and to explore the relationship between cell adhesion molecules and heart failure degrees.Methods Study included 35 CHF patients [19 cases of idiopathic dilated cardiomyopathy,11 cases of hypertension,5 cases of coronary heart disease(CHD)] and 18 healthy subjects.Serum sICAM-1 was measured by enzyme-linked immmunosorbent assay(ELISA).Diurnal variation of leukocyte CD18 expression in peripheral blood was assayed by flow cytometer.Serum BNP was measured by chemiluminescence.The diameter of left atrium(LA),left ventricle end-diastolic(LVED) and left ventricle end-systolic(LVES) and the left ventricular function were assessed by Doppler echocardiography Accuson Sequoia 512.Results There was no significant difference in the age between CHF group and control group(P0.05).However,the LA,LVEDV,LVESV,LVEF,sICAM-1,the leukocyte CD18 expression and the concentration of serum BNP were significantly higher in CHF patients than those in control group(P0.01).CHF patients were divided into three subgroups:NYHA Fc II,III and Ⅳ group.There was no significant difference in sICAM-1 and the leukocyte CD18 expression between three groups(P0.05),serum BNP was markedly higher in patients with NYHA Fc IV than in patients with NYHA Fc Ⅱ(P0.01).There was positive correlation between sICAM-1,CD18 and BNP(r=0.355,P=0.036;r=0.531,P=0.001,respectively).There was negative correlation between BNP,CD18 and LVEF(r=-0.542,P=0.001;r=-0.502,P=0.002,respectively).BNP value 450 pg/ml,sICAM-1 and CD18 in this subgroup(n=18) were 387.61±21.39μg/L and 64.73±2.91%,respectively;in another subgroup(BNP value 450 pg/ml n=17)were 314.47±24.10μg/L and 52.60±3.91%,respectively.There was significant difference between two subgroups(P=0.029 and 0.017,respectively).Conclusions Elevated levels of sICAM-1 and CD18 were found in the patients with CHF.Meanwhile,there was a positive correlation between levels of sICAM-1 and BNP,which indicated that chronic inflammation might be one of mechanisms in the development of CHF.Adhesion molecules might play an important role in the progression of CHF.We found poor correlation associated in sICAM-1 and the leukocyte CD18 expression in different heart function classes of CHF,While,referring to BNP,there was positive correlation between sICAM-1 and CD18 in different heart function classes of CHF." @default.
- W2370946598 created "2016-06-24" @default.
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- W2370946598 date "2008-01-01" @default.
- W2370946598 modified "2023-09-23" @default.
- W2370946598 title "Relationship between Cell Adhesion Molecules and B-type Natriuretic Peptide in Patients with Congestive Heart Failure" @default.
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