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- W2370950196 abstract "Objective To investigate the protective effect and its mechanism of tripterygium wilfordii polyglycoside(TWP) on the kidney of experimental diabetic rats.Methods The diabetes mellitus Sprague Dawley rats were induced by streptozotocin.The diabetic rats were randomly divided into three groups:control group,diabetic model group and TWP group(1.8 g·kg-1·d-1 orally administered once a day for 8 week).Blood sugar,serum creatinine,blood urea nitrogen at the end of the 8th week were measured and 24 h urine protein was measured.The superoxide dismutase(SOD) activity in the renal tissue,the level of malondia1dehyde(MDA) in the renal tissue and urine,the level of serum transformed growth factor-β1(TGF-β1) in urine,and the pathology changing of the rat kidney were observed.Results TWP can reduce the level of blood sugar,serum creatinine,blood urea nitrogen and 24 h urine protein,TWP also can reduce the level of MDA in the kindey and the level of serum TGF-β1.TWP increased the activity of SOD in the kindey and improved the renal histopathological changing.Conclusion TWP has a protective effect on the kidney of experimental diabetic rats.The mechanism may be related to the oxidative stress,enhancing the body's antioxidant capacity and decreasing the expression of TGF-β1." @default.
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- W2370950196 date "2012-01-01" @default.
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- W2370950196 title "Protective effect and mechanism of tripterygium wilfordii polyglycoside on the kidney in experimental diabetic rats" @default.
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