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- W2370953395 abstract "AIM: To investigate the effect of testosterone with varied concentrations on the fibr inolysis activity of HUVEC and its mechanism. METHODS: Human umbilical vein endothelial cells (HUVEC) were cul tured as recommended. After confluence, the cultures were treated with testoster one(3 ×10 -10, 3×10 -9, 3×10 -8,3×10 -6, 3×10 -5 m ol/L) , and the control confluent cells were cultured in the same medium witho ut steroid. MTT experiment was repeated for 72 hours to investigate each groups' cell proliferation. The tPA and PAI-1 antigen levels were assayed with ELISA K its. Then with HUVEC incubated in androgen receptor antagonist (flutamide) 3 hou rs previously, the experiment was repeated. RESULTS: Testosterone at physiologic or lower concentrations (3 ×10 -10 to 3×10 -8 mol/L ) stimulated the secretion of tPA by HUVEC (P0.01). However, tPA levels markedly reduced at larger doses (3 ×10 -6 to 3×10 -5 mol/L). On the other hand, PAI-1 antigen levels decrea sed significantly at the testosterone concentrations ranging from 3 ×10 -10 to 3×10 -5 mol/L (P0.05). Flutamide attenuated the testosteron e's effects (P0.05). CONCLUSIONS: The results indicated that testosterone at physiolo g ically relevant concentrations decreased PAI-1, while increased tPA levels via the androgen receptor, which suggested that testosterone may have beneficial eff ects on preventing thrombotic diseases." @default.
- W2370953395 created "2016-06-24" @default.
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- W2370953395 date "2005-01-01" @default.
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- W2370953395 title "Effects of testosterone on the fibrinolysis activity of HUVEC and its mechanism" @default.
- W2370953395 hasPublicationYear "2005" @default.
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