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- W2370957079 abstract "Objective:To investigate the effects of proteasome inhibitor PS-341(Bortezomib) on the expression of interleukin-6(IL-6),interleukin-1β(IL-1β) and stem cell factor(SCF) and the apoptosis of U266 cells. Methods:U266 Cells were incubated with RPMI1640 and exposed to 0,50,100,150,200 nmol/L of PS-341 for 4 h, respectively. Then the apoptosis of cells was analyzed by fluorescence microscope and flow cytometry(FCM) with Annexin V-FITC/PI double staining, and the expression of IL-6,IL-1β and SCF was detected by RT-PCR. Results:Fluorescence microscope and FCM showed that PS-341 induced U266 cells apoptosis in a dose-dependent manner; The expression of IL-6, IL-1β and SCF was decreased significantly after PS-341 treatment. The inhibitory effect on IL-6 and SCF was positively related with drug concentration. The expression of IL-1β was decreased gradually when the drug concentration was increased from 0 nmol/L to 150 nmol/L, whereas the expression level of IL-1β remained unchangeable when the drug concentration exceeded 150 nmol/L. Conclusion:Proteasome inhibitor PS-341 could significantly downregulate the expressions of IL-6,IL-1β and SCF in U266 cells, which might be one of the mechanisms for PS-341 for treatment of multiple myeloma." @default.
- W2370957079 created "2016-06-24" @default.
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- W2370957079 date "2007-01-01" @default.
- W2370957079 modified "2023-09-23" @default.
- W2370957079 title "Study on the effects of proteasome inhibitor PS-341 on apoptosis and expression of cytokines of U266 cells" @default.
- W2370957079 hasPublicationYear "2007" @default.
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