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- W2370960708 abstract "OBJECTIVE: To evaluate the curative effect and side effect of colloidal 32P and p53 gene for the treatment of malignant pleural effusion induced by lung cancer.METHODS: Totally 65 patients diagnosed as lung cancer with single side malignant pleural effusion were randomly divided into 3 groups.The patients of group A were treated by recombinant adenovirus p53 injection(rAD-p53) combined with colloidal chromic phosphate 32P(colloidal 32P).The patients of group B were treated by colloidal 32P.The patients of group C were treated by recombinant rAD-p53,per month.The therapeutic effects were evaluated after 2 courses.RESULTS: The total effective rate(CR+PR) was 81.8% in group A and 52.4% in group B and 40.9% in group C.There was no significant difference between group B and C(χ2=0.57,P0.05),but there was significant difference between A and 2 other groups(χ2 were 4.24 and 7.77 respectively,P0.05).CONCLUSION: The effect of individual use of colloidal 32P or rAd-p53 for the treatment of malignant pleural effusion induced by lung cancer is limited,the combination of both can effectively control pleural effusion induced by lung cancer." @default.
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- W2370960708 date "2012-01-01" @default.
- W2370960708 modified "2023-09-24" @default.
- W2370960708 title "Observation on the therapeutic effect of colloidal ~(32)P and p53 gene for the treatment of malignant pleural effusion induced by lung cancer" @default.
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