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- W2370970426 abstract "Aim To determine the effects of aerobic exercise training on aging-associated selective changes of the function of the spontaneous transient outward currents and the large-conductance Ca2 +-activated K+channels in cerebral arteries.Methods Male Wistar rats aged 19 ~ 21 months were randomly assigned to sedentary(O-SED) and exercisetrained groups(O-EX).Two-month-old rats were used as Young control.After 12 weeks,the segment of cerebral arteries was carefully dissected free,and separated into smooth muscle cells by two steps digestion.Results Whole-cell patch clamp showed that aging decreased the density of whole-cell K+current and iberiotoxin-sensitive whole-cell K+current; The amplitude of spontaneous transient outward currents was decreased by aging,while there was no significant difference in the frequency; Inside-out patch clamp recording on cerebral arteries myocytes showed that aging decreased the open probability and Ca2 +/ voltage sensitivity of single large-conductance Ca2 +-activated K+channel; The opening time was decreased by aging,whereas the close time was increased.However,exercise training inhibited all of these changes.Conclusion These data suggest that regular aerobic exercise can attenuate the functional downregulation of spontaneous transient outward currents / large-conductance Ca2 +-activated K+channels in aging cerebral arteries myocytes,which may be one of the important mechanisms underlying the beneficial effects of aerobic exercise on aging arteries." @default.
- W2370970426 created "2016-06-24" @default.
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- W2370970426 date "2015-01-01" @default.
- W2370970426 modified "2023-09-25" @default.
- W2370970426 title "Aerobic Exercise Attenuates Aging Induced Downregulation of STOC / BK_(Ca) Channels in Cerebral Arteries" @default.
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