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- W2370974489 abstract "Objective To explore the relationships between levels of liver fibrosis markers hyaluronic acid(HA), laminin(LN), procollagen type Ⅲ N-terminal endopeptidase(PⅢNP) and collagen type Ⅳ(CⅣ) in the serum and liver pathological changes, and study on the clinical application value of serum markers for non-traumatic liver fibrosis diagnosis in patients with hepatitis B. Methods The serum levels of HA, LN, PⅢNP and CⅣ were measured by radiommunoassay(RIA) in 172 patients with hepatitis B and liver biopsy was used as the gold standard, the correlation between the four serum markers and liver fibrosis were investigated and the diagnostic accuracy of four serum markers for obvious liver fibrosis was evaluated. Results There was a positive correlation between lvier fibrosis stage and these four serum markers. The correlation coefficient of HA, PⅢNP, CⅣ and LN were 0.687, 0.490, 0.406 and 0.392, respectively, without significant differences(P 0.05) in serum levels of these four markers between S0 and S1. The serum levels of these four markers increased obviously from S2 to S4 which were significantly different compared with S1(P 0.05). Also, there were significant differences in serum levels of these four markers between patients with no significant fibrosis(S0-S1) and significant fibrosis(S2-S4)(P 0.05). The area under receiver operating characteristic(ROC) curve of HA, PⅢNP, CⅣ and LN were 0.846, 0.786, 0.747 and 0.638, respectively. The sensitivities of HA, LN, PⅢNP and CⅣ for predicting significant fibrosis were 75.16%, 80.57%, 69.54% and 73.38%, respectively. While the specificities were 90.25%, 65.50%, 81.89% and 71.51%; the accuracies were 83.18%, 68.46%, 75.74% and 62.53%, respectively. When these four markers were all used for a combined assay, the specificity of diagnosis was increased to 92.96% and the accuracy was increased to 86.44%, while the sensitivity of diagnosis was reduced to 68.85%. Conclusions HA is the best serum marker for diagnosis of liver fibrosis. The specificity and accuracy would be increased with combined assay. The assay of these four serum markers were proved particularly effective in the diagnosis of hepatic fibrosis in patients with hepatitis B." @default.
- W2370974489 created "2016-06-24" @default.
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- W2370974489 date "2013-01-01" @default.
- W2370974489 modified "2023-09-27" @default.
- W2370974489 title "Correlation between serum markers of liver fibrosis and liver pathological changes" @default.
- W2370974489 hasPublicationYear "2013" @default.
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