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- W2370982105 abstract "Located in kinetochore, highly expressed in cancer (Hec1) is a protein highly expressed in cancer. The electrostatic interaction between the N-terminal tail of Hec1 and microtubule promotes the formation of kinetochore-microtuble attachments. Hec1p, Nuf2p, Spc24p and Spc25p constitute the Ndc80 complex which is located in the outer plate of kinetochore. Ndc80 complex plays a role in modulating normal chromosomal segregation together with other kinetochore proteins. The expression of Hec1 has a dynamic change with the process of cell cycle and is higher in cells undergoing active mitosis such as tumor cells. Hec1 is a target for tumor gene therapy, and the introduction of Hec1-siRNA into cervical adenocarcinoma cells or glioblastoma cells by different virus vectors such as adenovirus, rAAV and retrovirus vectors finally leads to apoptosis of tumor cells." @default.
- W2370982105 created "2016-06-24" @default.
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- W2370982105 date "2009-01-01" @default.
- W2370982105 modified "2023-09-25" @default.
- W2370982105 title "Hec1 and its application in tumor gene therapy" @default.
- W2370982105 hasPublicationYear "2009" @default.
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