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- W2371001044 abstract "Objective To investigate the effect of Ginkgo biloba extract EGb761 on the healing of nerve injury after spinal cord injury in rats.Methods 120 SD rats were randomly divided into sham group,injury control group,methylprednisolone(MP) treated group and EGb761 treated group,30 rats for each group.The spinal cord injury model was established by modified Allen method.The recovery of neurological function after SCI in rats was observed with inclined plane test and BBB score.Pathological changes of spinal cord were observed through HE staining.IL-10 in spinal cord was conducted by ELISA.Results Compared to the injury control group,the critical angle,BBB score and IL-10 increased obviously in MP and EGb761 treated groups in the seventh and the fourteenth day after spinal cord injury.HE staining showed that there were hemorrhage,edema,necrosis,axonal demyelination,infiltration of inflammatory cells and astroglial responses in spinal cord in injury control group.In contrast,edema,inflammatory reaction,neuronal degeneration and necrosis were much less in MP and EGb761 treated groups in the seventh day after spinal cord injury.Conclusion EGb761 can alleviate the secondary spinal cord injury and promote the recovery of nerve injury after spinal cord injury in rats." @default.
- W2371001044 created "2016-06-24" @default.
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- W2371001044 date "2010-01-01" @default.
- W2371001044 modified "2023-10-15" @default.
- W2371001044 title "Effect of Ginkgo biloba extract EGb761 on healing of nerve injury after spinal cord injury in rats" @default.
- W2371001044 hasPublicationYear "2010" @default.
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