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- W2371007341 abstract "Objective:To study the reversal effec t of emodin(EMD) on the multidrug resistance cell line—MCF7/ADR.Methods:Using tetrazolium dye asscry,effects of various concentrations of EMD on sensitivity to ADR in MCF7/ADR was studied.And P-glycoprotein was measured by western-blot.Results:EMD was safe below 20μmol/L for fourteen days,af ter EMD 10μmol/L treatment,the chemosensitivity to ADR increased to 1.7 times.Af ter treatment with 20μmol/L EMD,the expression of P-glycoprotein began to decli ne on the 4 th day,and when the 11 th day no P-glycoprotein could be m easured.Conclusion:EMD has reversal effects on MDR in MCF7/ADR,P -glycoprotein expression can be inhibited and the effect is long." @default.
- W2371007341 created "2016-06-24" @default.
- W2371007341 creator A5085594231 @default.
- W2371007341 date "2004-01-01" @default.
- W2371007341 modified "2023-09-28" @default.
- W2371007341 title "Study of the reversal effect of Emodin on the multidrug resistance cell line—MCF-7/Adr" @default.
- W2371007341 hasPublicationYear "2004" @default.
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