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- W2371010997 abstract "OBJECTIVE:To study the pharmacokinetics of Flucloxacillin magnesium granules and Flucloxacillin sodium capsules in healthy volunteers. METHODS:24 subjects were randomized into 2 groups and enrolled in bi-periodic crossover test. They were given test preparation Flucloxacillin magnesium granules or reference preparation Flucloxacillin sodium capsules of 0.5 g. Plasma concentrations of flucloxacillin were determined by LC-MS/MS. The main pharmacokinetic parameters were calculated,and bioequiavailability of them were compared. RESULTS:The main pharmacokinetic parameters of test preparation vs. reference preparation were as follows:t1/2(1.53±0.29)h vs(.1.55±0.25)h;cmax(34.56±8.13)mg/L vs(.34.67±8.89)mg/L;tmax(0.72±0.25)h vs.(0.74±0.25)h;AUC0-24 h(69.51±15.34)mg·h/L vs(.70.47±16.19)mg·h/L. The relative bioavailability of test preparation was(99.29±10.34)%. CONCLUSIONS:The results demonstrate that the two preparations are bioequivalent." @default.
- W2371010997 created "2016-06-24" @default.
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- W2371010997 date "2014-01-01" @default.
- W2371010997 modified "2023-09-27" @default.
- W2371010997 title "Study on Bioequivalence of Flucloxacillin Magnesium Granules in Healthy Volunteers" @default.
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