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- W2371014302 abstract "[Objective] To investigate the effect of Lycium barbarum polysaccharide (LBP) on T-lymphocyte subsets levels, dendritic cells (DCs) counting and antigen CD80 expression in peripheral blood and tumor stroma of H22-bearing mice. [Methods] H22-bearing mice models were established. LBP in the dosages of 1.25 and 0.625 g·kg-1·d-1 was orally administered to the mice models for two weeks. The changes of T-lymphocyte subsets levels, DCs counting and antigen CDgo expression in peripheral blood and tumor stroma were detected by flow cytometry (FCM) . [ Results ] LBP increased the numbers of CD4+ and CD8+ T-cells, promoted the proliferation of CD4+ T-cells, and elevated the ratio of CD4+ /CD8+ in peripheral blood. LBP in large dosage also increased the numbers of CD4+ and CD8+ T-cells in the tumor-infiltrating lymphocytes (P 0.05 compared with the model group) . The number of DCs in tumor stroma decreased markedly in the model group, and LBP increased DCs number and CD80 expression, the effect being parallel with that in T-lymphocyte subsets. The differences of DCs number and CD80 expression in the three groups were not significant. [Conclusion] The anti-tumor mechanism of LBP may be related to the recovery of CD4+ and CD8+ T-cells number, thus relieving the immune suppression and enhancing anti-tumor function of immune system." @default.
- W2371014302 created "2016-06-24" @default.
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- W2371014302 date "2005-01-01" @default.
- W2371014302 modified "2023-09-26" @default.
- W2371014302 title "Effect of Lycium Bar bar um Polysaccharide on T-lymphocyte Subsets and Dendritic Cells in H_(22)- bearing Mice" @default.
- W2371014302 hasPublicationYear "2005" @default.
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