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• W2371014989 abstract "Objective To investigate the frequency of CD4+CD25+Foxp3+ regulatory T cells( Treg) in peripheral blood of patients with chronic hepatitis B( CHB) and its significance in the hepatitis B virus( HBV) infection. Methods The frequencies of CD4+CD25+Foxp3+ Treg in peripheral blood from 86 CHB patients,30 acute hepatitis B( AHB)patients and 30 healthy subjects were determined by flow cytometry. The correlations of HBV DNA loads with CD4+CD25+Foxp3+Treg frequency and the frequency of CD4+CD25+Foxp3+ Treg after therapy with different therapeutic effects were analyzed respectively. CD4+CD25+Foxp3+Treg frequencies among mild,moderate and severe active CHB patients were compared respectively. Results The percentages of CD4+CD25+Foxp3+ Treg in CHB patients,AHB patients and healthy subjects were 2. 56% ± 1. 12%,1. 39% ± 0. 68% and 1. 45% ± 0. 76%,respectively. The percentage in CHB patients was higher than those in AHB patients and healthy subjects( P 0. 05),and there was no statistical significance between the percentages of AHB patients and healthy subjects( P 0. 05). The percentages of CD4+CD25+Foxp3+ Treg among mild,moderate and severe active CHB patients had no statistical significance( P 0. 05). The levels of alanine aminotransferase( ALT) in CHB patients,AHB patients and healthy subjects were 285. 6 ±168. 3,( 780. 9 ± 432. 6) and( 23. 2 ± 6. 7) U / L,respectively. The levels of ALT in CHB patients and AHB patients were higher than that in healthy subjects( P 0. 05). The level of ALT in CHB patients was lower than that in AHB patients( P 0. 05). The frequency of CD4+CD25+Foxp3+ Treg was not correlated with the level of ALT( r = 0. 11,P 0. 05). The HBV DNA loads in CHB patients,AHB patients and healthy subjects were( 5. 2 ± 1. 8) log10 copies / mL,( 7. 2 ±1. 8) log10 copies / mL and negative respectively. The HBV DNA load in AHB patients was higher than that in CHB patients( P 0. 05). There was a positive correlation between CD4+CD25+Foxp3+ Treg frequency and HBV DNA logarithm( r = 0. 30,P 0. 05). CD4+CD25+Foxp3+ Treg frequency decreased obviously after anti-viral therapy in the patients with obvious good therapeutic effect,and it was lower than that in the patients with poor therapeutic effect( P 0. 05). Conclusions The increase of CD4+CD25+Foxp3+ Treg in CHB patients plays an active role in chronic HBV.The regulation and control of function and amount of CD4+CD25+Foxp3+ Treg may provide a new therapy for CHB." @default.
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• W2371014989 date "2013-01-01" @default.
• W2371014989 modified "2023-09-26" @default.
• W2371014989 title "Analysis on the change of CD4~+CD25~+Foxp3~+ regulatory T cells in peripheral blood of patients with chronic hepatitis B" @default.
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