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- W2371026183 abstract "[Objective] To explore the lethal effect of epirubicin (E-ADM) on K562 cells and its possible mechanism. [Methods]The percentage and mean fluorescence intensity (MFI) of cell spontaneous fluorescence(SF), cell mortality rate (PI), and P170 expression of K562 cells were analyzed by flow cytometry after the co-incubation of E-ADM with different concentrations and different time span. [Results]The positive rate of SF, PI and P170 started to increase at 0.01μg∕ml E-ADM, and increased immediately accompanied the effecting curve as a S type, and the effects at 24h were superior to those at 72h. The positive rate of SF, PI and P170 expression increased with the concentration of E-ADM, though without significantly positive correlation (P0.05). Significantly positive correlation existed between the MFI of SF, PI and P170 expression and the concentration of E-ADM (P0.01), as well as among the three markers (P0.01). [Conclusion]E-ADM has obvious lethal effects on K562 cells with a dosage sensitive region, optimistic lethal concentration and the most suitable incubating time, which is positively related to E-ADM concentration. The results can provide valuable reference evidence for the clinical application of E-ADM." @default.
- W2371026183 created "2016-06-24" @default.
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- W2371026183 date "2008-01-01" @default.
- W2371026183 modified "2023-09-23" @default.
- W2371026183 title "Lethal Effect of Epirubicin on K562 Cells" @default.
- W2371026183 hasPublicationYear "2008" @default.
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