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- W2371032600 abstract "Objective To study the correlation of polymorphisms of SULT1A1 with the risk of esophageal cancer and smoke-gene interaction.Methods 163 cases of esophageal cancer and 166 controls were collected from Heping hospital and Heji hospital of Changzhi in Shanxi Province.Blood sample were collected for detecting SULT1A1 polymorphisms by PCR and RFLP.Results ①There was no significant difference in genotype of Arg/Arg,Arg/His and His/His of SULT1A1 between cases and controls(P=(0.60));The frequencies of His allele were(17.79%) and(12.57%) in cases and controls,respectively((P0.05));the risk was significantly higher in people with His allele(OR_(adjusted)=1.868,95% CI was 1.107~3.153).②There was an interaction existed between smoking and the variant SULT1A1 after adjusting some confounding factors (OR=2.802,95% CI was 1.257~6.246).(③Heavy) smokers with His allele had 8.538-fold higher risk(95% CI was 1.633~44.624).Conclusions A genetic polymorphism in the SULT1A1 gene may be associated with increased esophageal cancer,and an interaction existed between smoking and the variant SULT1A1." @default.
- W2371032600 created "2016-06-24" @default.
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- W2371032600 date "2006-01-01" @default.
- W2371032600 modified "2023-09-25" @default.
- W2371032600 title "Relationship between SULT1A1 gene polymorphisms and susceptibility to esophageal cancer" @default.
- W2371032600 hasPublicationYear "2006" @default.
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