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- W2371033171 abstract "Objective To separate the side population(SP) of cancer stem-like cells from lung cancer A549 cells,and to investigate the effect of gefitinib on the proliferation and cell cycle of A549 SP cells.Methods A549 SP cells were isolated by flow cytometry with Hoechst 33342 and PI staining and then were exposed to different concentrations of gefitinib(0-40 μmol·L-1) for 24,48 and 72 hours. Cell proliferation was detected by MTT.Cell cycle distribution was detected by flow cytometry. Results The treatment with verapamil decreased the percentage of SP cells from 1.89% to 0.39%.The treatment with gefitinib(0-40 μmol·L-1) significantly inhibited the p roliferation of A549 SP cells in a dose-and time-dependent manner.Flow cytometry showed that gefitinib treatment inhibited the proliferation of A549 SP cells by inducing G0/G1 arrest.Conclusion Lung cancer A549 cells contain SP cells.The gefitinib can inhibit the proliferation of A549 SP cells by causing G0/G1 phase cell cycle arrest." @default.
- W2371033171 created "2016-06-24" @default.
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- W2371033171 date "2012-01-01" @default.
- W2371033171 modified "2023-09-28" @default.
- W2371033171 title "Effect of Gefitinib on Proliferation of Human Lung Cancer A549 Cells" @default.
- W2371033171 hasPublicationYear "2012" @default.
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