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- W2371045558 abstract "Objective To investigate the effect of nutritional support therapy on severe acute pancreatitis(SAP).Methods A total of 96 patients with SAP were divided randomly into control group and treatment group.The former group received total parenteral nutrition(TPN) via central venous infusion,while parenteral nutrition(PN) and enteral nutrition(EN) therapies were applied in different phases for the latter group.The nutrition status,acute phase responses,pancreas lesions,enteric mucosa penetrability and immune functions were monitored.Results Body mass and prealbumin concentration were increased in treatment group,compared to those in control group(P0.05),but albumin concentration did not change significantly.Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ) scores decreased after 7 days of treatment,whereas the scores of control group decreased on the 11th day.Concentrations of tumor necrosis factor-α(TNF-α),interleukine-6(IL-6) and serum C reactive protein(CRP) dropped earlier in treatment group(on the 4th day) than those in control group(on the 7th day).No statistic difference was observed in pancreatic lesions between control group and treatment group.Concentration of endotoxin and lactulose/manicol(L∶M) ratio of urine did not change in treatment group,but those in control group were elevated markedly.Compared with treatment group,CD4:CD8 T cells ratio and immunoglobulin G(IgG) concentration in control group decreased significantly(P0.05).Conclusion Compared to TPN,the combined therapy of EN and PN could improve the nutrition status and relieve the acute phase response obviously.Moreover,the integrity of enteric mucosa and immune function were protected more effectively in treatment group than in control group.On the other hand,EN did not simulate the excretion of pancreas and avoid exaggerating the inflammation of pancreas.Thus,appropriate application of PN and EN appears to be more effective for patients with SAP." @default.
- W2371045558 created "2016-06-24" @default.
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- W2371045558 date "2011-01-01" @default.
- W2371045558 modified "2023-09-23" @default.
- W2371045558 title "Clinical study on nutrition support in patients with severe acute pancreatitis" @default.
- W2371045558 hasPublicationYear "2011" @default.
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