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- W2371052904 abstract "Objective To study electrophysiological mechanism of paroxysmal atrial fibrillation and effect of right atrial isthmus ablation on the occurrence of atrial fibrillation(AF). Methods From June,1995 to June,1999, 15 patients[8 men,7 women,mean age (56±9) years] with drug refractory paroxysmal atrial fibrillation were studied.The history of AF was mean (7±4) years.The episodes of AF from six a month to more than twenty times a day had been documented within recent three months before study, which lead to severe symptoms. There were 15 patients (5 men,10 women, mean age 57±6 years) with artioventricular nodal reentry tachycardia(AVNRT)in control group.All patients underwent electrophysiological study, the cycle length of Wenckebach point of the atrioventricual node was measured, both antegradly and retrogradly. The programmed electrical and burst(200,300 ms) stimuli were used in high right atrium to induce the arrhythmia.Right atrial isthmus(from tricuspid annulus to inferior vena cava)linear ablation was performed in AF group. Results The antegrade and retrograde Wenckebach cycle length in AF was (340±38) and 618±75ms, respectively,(345±52) ms and (338±48) ms in AVNRT. The retrograde Wenckebach cycle length was much longer than antegrade one in AF ( P 0 001),but no significance in AVNRT group ( P 0 05). The dispersion of Wenckebach cycle length(retrograde subtracts antegrade) increased significantly in AF group compared with AVNRT group ( P 0 001).AF could be induced by burst stimuli in all AF patients.Atrial flutter (AFL) degenerated into AF in 9 patients. After ablation of right atrial isthmus,the AF and AFL could not be induced in 7 patients. AF did not recur in 3 patients without medication during a follow up period of 3 months to 4 years,the longest period of follow up was 3 years and 6 months. The episodes of AF decreased about 70%～95% and symptoms were improved significantly in others. Conclusion Some paroxysmal AF has the same macroreetrant circuit in right atrium as AFL in this study,and AFL could degenerate into AF.The macroreentrant circuit and its electrophysiological characteristic and increasing dispersion of Wenckebach cycle length may play an important role in inducing and persisting of AF and AFL in these pstients.The ablation of right atrial isthmus can prevent some paroxysmal AF from recurrence or reduce its episodes and improve symptoms." @default.
- W2371052904 created "2016-06-24" @default.
- W2371052904 creator A5003124726 @default.
- W2371052904 date "2000-01-01" @default.
- W2371052904 modified "2023-09-23" @default.
- W2371052904 title "Preliminary study of electrophysiological mechanism and radiofrequency catheter ablation of paroxysmal atrial fibrillation" @default.
- W2371052904 hasPublicationYear "2000" @default.
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