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- W2371053046 abstract "Objective To explore the genotoxicity of 1,2-dichloroethane and to study the effect on damages of DNA in peripheral and chromosome in marrow cell of mice.Methods Damages of DNA and chromosome induced by 1,2-dichloroethane at different dosages(50,100,200,400 mg/kg)were detected using alkaline single cell gel electrophoresis(SCGE)of mice peripheral blood cell and micronucleus assay of mice bone marrow cell.Results Except for 50 mg/kg group,the number of comet cells and the length of DNA migration in peripheral blood cell,the mice bone marrow micronucleus frequency increased significantly as the exposure dose increased(P0.01).Among the rest groups,the ratio of comet cells,the length of DNA migration in peripheral blood cell and the ratio of micronucleus in mice bone marrow in 400 mg/kg group were 45.5%,(37.24±3.17)μm and 12.0‰ respectively and were significantly higher than that of the negative control and 50 mg/kg group(P0.01).Between the exposure doses and the percentage of damages of DNA in peripheral blood cell and chromosome in marrow,there was a dose-response relationship(P0.01).Conclusions 1,2-dichloroethane could induce damages of DNA in peripheral blood cell and chromosome in marrow cell of mice.The results suggest that 1,2-dichloroethane shows significant genotoxicity." @default.
- W2371053046 created "2016-06-24" @default.
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- W2371053046 date "2007-01-01" @default.
- W2371053046 modified "2023-09-23" @default.
- W2371053046 title "Study on the Genotoxicity of 1,2-Dichloroethane in Blood Cell of Mice" @default.
- W2371053046 hasPublicationYear "2007" @default.
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