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- W2371069854 abstract "Objective To explore the effects and mechanism of chronic stress on cytoskeleton of dendrites in the rat hippacampal CA3 neurons.Methods Sixteen male Sprague-Dawley rats were randomly divided into two groups(8 in each),one was given 4-week forced-swimming to make stress model The ultrastructure of dendritic microtubules was observed by using an electron-microscope.The level of phosphorylated MAP2 in rat hippocampal CA3 pyramidal neurons was detected with immunohistochemistry method.Results The destroyed changes of cytoskeleton were observed in hippocampal CA3 pyramidal neuronal dendrites in the stress group.The average gray degree of phosphorylated MAP2 in hippocampal CA3 pyramidal neurons was significantly lower in the stress group(145.0±4.4)than that in control group (149.3±1.8);and the number of neurons(40.36±1.36)was significantly less than that of control group (42.73±1.56).Conclusion It is suggested that chronic stress could damage the cytoskeleton of dendrites in rat hippocampal CA3 pyramidal neurons through enhancing level of phosphorylation of MAP2." @default.
- W2371069854 created "2016-06-24" @default.
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- W2371069854 date "2007-01-01" @default.
- W2371069854 modified "2023-09-28" @default.
- W2371069854 title "Effects of chronic stress on cytoskeleton of dendrites in rat hippocampal CA3 neurons and its relevant mechanism" @default.
- W2371069854 hasPublicationYear "2007" @default.
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