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- W2371070356 abstract "Objective To explore the relationship between the CAG microsatellite in androgen receptor(AR)gene and the biological behavior of prostate cancer(PC).Methods The number of CAG repeats in exon 1 of the AR gene was measured in 113 PC tissues by polymerase chain reaction single strand conformation polymophism(PCR SSCP)analysis.The number of CAG repeats was tested to determine its association with stages and grades of PC among the three races.Results The average number of CAG repeats was statistically different between stage B and stage C～D in Chinese 25.04±1.88 and 22.14±2.64( P 0.01),in the non Hispanic white 23.74±2.49 and 21.97±3.31( P 0.05),in African American patients 21.75±1.10 and 19.46±3.14( P 0.05).The short CAG(22) was differently distributed to the stage B and stage C～D: 13.0%(3/23) and 28.6%(4/14) in Chinese( P 0.05), 14.8% (4/27)and 36.7%(11/30)in non Hispanic white( P 0.05),25.0%(1/4)and 80.0%(12/15)in African American patients( P 0.05).The averages CAG repeat number increase along with in low,middle and high differentiation of tumor tissues:23.64± 2.56 ,24.29±3.45,25.6±1.67 in Chinese;21.44±4.03,23.11±1.79,23.81±2.81 in non Hispanic Whit;19.57±2.56,21.33±0.47,21.00±0.00 in African American patients.The distributions of short CAG dropped with in low,middle and high differentiation of PC:60.0%(15/25),28.6%(2/7),0%(0/5)in Chinese;50.0%(9/18),22.2%(4/18),14.3%(3/21)in non Hispanic Whit;71.4%(10/14),33.3%(1/3),0%(0/2)in African American patients.The difference between in high and low differentiation of PC is significant among the three races( P 0.05).The stage C～D and low differentiation of PC were more in African American(78.9% and 73.7%)than in non Hispanic Whit patients(52.6% and 31.6%) and the averages of CAG repeat number were less in African American(19.89±2.95)than in non Hispanic Whit patients(22.95±2.97).Conclusion The number of CAG in AR gene may be a factor of the makeup feature of PC in biology and the PC that contains short CAG in AR presents high aggression." @default.
- W2371070356 created "2016-06-24" @default.
- W2371070356 creator A5063479093 @default.
- W2371070356 date "2001-01-01" @default.
- W2371070356 modified "2023-09-25" @default.
- W2371070356 title "The Polymorphism of CAG Microsatellite in the Androgen Receptor Gene and the Biological Behavior of Prostate Cancer" @default.
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