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- W2371072010 abstract "Objective Glutamine has protective effects against renal injuries.This study was designed to explore the possible mechanism underlying the protections by examining the effects of glutamine on extracellular signal regulated kinase(ERK) and P38 expression in the small intestine in rats with endotoxemia.Methods Ninety 18-day-old Wistar rats were randomly injected with LPS(5 mg/kg;n = 40),LPS(5 mg/kg) + glutamine(2 g/kg)(n = 40),or normal saline(control group;n = 10).Entire ileums were collected at different time points including 2 h,6 h,24 h and 72 h after dosing,10 rats per time point.They were fixed in 4% polyformaldehyde and embedded in paraffin.ERK-2 and P38 protein expression in the small intestine were measured by immunohistrochemistry.Results Compared to the control group,protein expression of both ERK-2 and P38 in LPS group significantly increased at 2 h,6 h,24 h and 72 h after administration(P 0.01),and reached a peak at 6 h(P 0.01).In LPS + glutamine group,the trend of ERK-2 and P38 expression was similar to LPS group but their expressional levels were significantly lower than LPS group at all time points(P 0.05).Conclusion Both ERK-2 and P38 expression increased in young rats with LPS-induced endotoxemia.Glutamine alleviates renal injuries possibly through the decreasing of these two proteins." @default.
- W2371072010 created "2016-06-24" @default.
- W2371072010 creator A5053051342 @default.
- W2371072010 date "2012-01-01" @default.
- W2371072010 modified "2023-09-25" @default.
- W2371072010 title "Effects of Glutamine on Extracellular Signal Regulated Kinase and P38 Expression in Small Intestine in Young Rats with Endotoxemia" @default.
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