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- W2371097384 abstract "AIM To study the mechanism of abnormal gallbladder (GB) emptying in patients with bile reflux gastritis (BRG). METHODS GB emptying function and the effect of nifedipine on it were studied by using real time ultrasonography in thirty eight BRG patients and 30 normal controls by randomized, double blind controlled methods. RESULTS Fasting GB volume was higher in BRG patients than in controls ( P 0 01) and no notable change was found before and after taking nifedipine ( P 0 05) . GB ejection fraction (GEF) was markedly decreased 15min after the meal, and the decrease was more significant at 45min postprandial in BRG patients compared with controls ( P 0 01) . The GEF was significantly increased 25min after taking oral nifedipine 10*!mg ( P 0 01) , and even more marked after 20*!mg nifedipine ( P 0 01) in BRG patients than in controls. The speed of GB emptying was faster 60min after the meal ( P 0 01) , and maximum GEF time was notably shortened after oral nifedipine ( P 0 01) in BRG patients. No notable difference was found in the concentration of plasma motilin before and after taking nifedipine ( P 0 05). In controls GEF was markedly decreased after taking nifedipine 10*!mg ( P 0 01), and more marked after taking nifedipine 20*!mg . CONCLUSION One of mechanisms of abnormal GB emptying in BRG patients may be dysrelaxation of Oddi sphincter; nifedipine can significantly improve postprandial (but not fasting) GB emptying function, which does not depend on motilin." @default.
- W2371097384 created "2016-06-24" @default.
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- W2371097384 date "1999-01-01" @default.
- W2371097384 modified "2023-09-28" @default.
- W2371097384 title "Dysrelaxation of Sphincter of Oddi in patients with bile reflux gastritis: study on effect of nifedipine on gallbladder emptying" @default.
- W2371097384 hasPublicationYear "1999" @default.
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