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- W2371105145 abstract "Vasoactive intestinal peptide( VIP) is a linear cationic neuropeptide containing 28 amino acids,and its molecular weight is 3323. VIP exhibited a wide range of biological functions as a neuroendocrine hormones,neurotransmitter and cytokines,including relaxing vessels,promoting gastric peristalsis,modulating the immune system and protecting the central nervous system. The study on animal models demonstrated that VIP was an attractive therapeutic candidate. The pathological characters of models were distinctly improved after treating with VIP in the form of liposome,nanoparticle,recombinant plasmid or VIP gene. Therefore,it becomes reliable theoretical basis and has expansive application prospect to develop VIP or its derivates toward the potential drugs. However some obstacles still exist between the laboratory and the clinic,mainly because of its structural unstability,high sensitivity to protease degradation and complex biological actions. To comprehensively understand the research methods and progresses of VIP,its molecular characters,the mediated processes of VIP receptors( VPAC),its biological functions and prospective of developing it toward drugs are reviewed. In addition,some suggestions on modification of VIP to make it more stable are proposed based on the author's work." @default.
- W2371105145 created "2016-06-24" @default.
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- W2371105145 date "2013-01-01" @default.
- W2371105145 modified "2023-09-27" @default.
- W2371105145 title "Research Progress in Vasoactive Intestinal Peptide" @default.
- W2371105145 hasPublicationYear "2013" @default.
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