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- W2371111146 abstract "Objective To study the immunoglobulins( Ig) , lactate dehydrogenase( LDH) and adenosine deaminase( ADA) activity in cerebrospinal fluid(CSF) for differential diagnosis of three type meningitis. Methods Immunoglobulins, lactate dehydrogenase and adenosine deaminase in cerebrospinal fluid were measured in 15 cases of tuberculous meningitis, 18 of purulent meningitis, 20 of viral meningitis and compared with 16 control cases. Results The concentrations of LDH, ADA, IgM, IgG, IgA in CSF of the patients with purulent meningitis were (85.62± 18.13)U/L, (2.58± 0.52)U/L, (63.84± 13.43)mg/L, (92.57± 35.19)mg/L, (20.62± 8.74)mg/L, respectively; their levels in tuberculous meningitis group were (78.83± 22.39)U/L, (11.82± 2.64)U/L, (18.91± 8.62)mg/L, (180.70± 42.29)mg/L, (41.61± 11.42)mg/L, respectively; their levels in viral meningitis group were (22.42± 9.57)U/L, (2.65± 0.64)U/L, (5.83± 1.34)mg/L, ( 20.91± 10.34)mg/L, (7.20± 2.31)mg/L, respectively. The concentrations of IgM, IgG, IgA, LDH in CSF of the patients with tuberculous meningitis or purulent meningitis were significantly higher than those in viral meningitis( IP/II/I0.01) , the levels of IgG and IgA in the patients with tuberculous meningitis were significantly higher than those in other two groups, while the level of IgM in the patients with purulent meningitis was significantly higher than that in other two groups(IP/I0.01); the level of ADA in the patients with tuberculous meningitis was significantly higher than that in other two groups(IP/I0.01); There were no significant differences in these parameters between viral meningitis group and control group(P0.05). Conclusions The concentrations of Ig, LDH in CSF are helpful to diagnosis and differentially diagnosis of three type meningitis. The level of ADA in CSF has important clinical value to diagnosis of tuberculous meningitis." @default.
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- W2371111146 date "2006-01-01" @default.
- W2371111146 modified "2023-09-23" @default.
- W2371111146 title "Detection of immunoglobulins, lactate dehydrogenase and adenosine deaminase in cerebrospinal fluid for the differential diagnosis of three type meningitis" @default.
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