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- W2371124523 abstract "Objective: To investigate the protective effect of Sargassum Fusiforme Polysaccharides(SFPS) on HL-7702 cells against apoptosis induced by palmitic acid(PA) in culture,and then to explore the mechanism of SFPS against apoptosis.Methods: HL-7702 cells were exposed to PA to mimic apoptosis.To explore the effects of SFPS on the HL-7702 cells subjected to PA injury,cells were pretreated with SFPS 25,50,100μg/mL for 24h,respectively,and then exposed to 0.5mmol/L PA for 48h.The cell viability was measured by MTT colorimetric assay;Apoptotic cells were detected by Annexin V-FITC/PI double labeled flow cytometry;The expression of Bcl-2 mRNA,Bax mRNA and Bcl-2/Bax were checked up by Reverse transcription PCR(RT-PCR).Results: The results showed that PA treatment significantly decreased the cell viability,increased the percentage of apoptotic cells.Pretreatment of SFPS at different concentrations(25、50、100μg/mL)could remarkably increase the cell viability of hepatocytes.Compared with that of PA group(64.9±3.5)%,the cell viabilities of hepatocytes treated with 25,50 and 100 ug/ml SFPS increased to(70.0±3.0)%、(75.5±3.3)%、(84.1±3.7)%(P0.05),respectively.The apoptotic rate of PA group was(39.8±4.7)%,while that of SFPS groups decreased significantly to(35.5±5.2)%、(28.2±3.3)%、(17.1±2.8)%(P0.05),respectively.Moreover,as detected by RT-PCR,the expression of Bax mRNA decreased,while that of Bcl-2 mRNA and Bcl-2/Bax increased significantly.Conclusion: These results suggest that SFPS has a protective effect on HL-7702 cells against apoptosis induced by PA,which might be related to regulating the expression of Bcl-2 and Bax in hepatocytes." @default.
- W2371124523 created "2016-06-24" @default.
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- W2371124523 date "2011-01-01" @default.
- W2371124523 modified "2023-09-23" @default.
- W2371124523 title "Protection of Sargassum Fusiforme Polysaccharides Against Palmitic Acid-induced Apoptosis on HL-7702 Cells" @default.
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