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- W2371139612 abstract "Objective:To investigate the apoptotic effect of H2O2 in rat pheochromocytoma(PC12) cell line.Methods The cell viability was analyzed by MTT;the morphological changes were observed by Hoechst 33 258 staining analysis;the ultrathin sections of cells were observed by transmission electron microscopic(TEM);the apoptosis rate,the protein of Bcl-2 and Bax were measured by the flow cytometry analysis(FCM and Western blotting);the Caspase-3 activation was measuredusing Microplate Fluorometer.Results:H2O2(0.25 mM) could result in the decrease of cell viability,the increase of Bax and the dropping of Bcl-2 protein expression of PC12 cell.It increased the activity of Caspase-3 and the apoptotic rate of cells.Conclusions:The apoptosis in H2O2-induced PC12 cells was accompanied by down-regulation of Bcl-2,up-regulation of Bax and sequential activation of Caspase-3." @default.
- W2371139612 created "2016-06-24" @default.
- W2371139612 creator A5083228558 @default.
- W2371139612 date "2011-01-01" @default.
- W2371139612 modified "2023-09-23" @default.
- W2371139612 title "Expression of Apoptosis Pathway Proteins Modulates H_2O_2-induced Apoptosis in PC12 Cells" @default.
- W2371139612 hasPublicationYear "2011" @default.
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