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- W2371141275 abstract "With recognition of biological functions of brown adipose tissue(BAT) in adults, it has become a hot topic in medical research. In the present study, the effects of(-)-Epigallocatechin-3-gallate(EGCG) on the metabolism of BAT are investigated through animal experiments, histopathologicaland immunohistochemical methods. The results show that there are disparities in morphology of interscapular BAT among different species of mice. Vacuoles of fat droplets in adipocytes of C57BL/6 mice are the largest, and the cytoplasmic content is the least. Vacuoles in adipocytes of BALB/c mice are the smallest, and the cytoplasmic content is the most. Vacuoles and cytoplasmic content in Kunming mice lie between those in C57BL/6 and BALB/c mice. EGCG at 150 mg/kg decreases the increment rate of body weight and reduces the weights of epididymal white adipose tissue, but there is no statistical significance after different doses of EGCG are administered p.o. to Kunming mice. EGCG significantly decreases the content of fat(shown as vacuoles in the sections) in BAT and increases the cytoplasmic content(P0.001). By immunohistochemical examination, EGCG increases the expression level of uncoupling protein 1, indicating the increase of energymetabolism in BAT. Therefore, there exist diversemorphological characteristics in different inbred lines of mice, which provides the basis for selection of mice in BAT studies. EGCG may regulate the metabolism of BAT in mice, which lays the foundation for further studies of its mechanism and provides new ideas for studies of the regulation of fat metabolism by tea." @default.
- W2371141275 created "2016-06-24" @default.
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- W2371141275 date "2014-01-01" @default.
- W2371141275 modified "2023-09-27" @default.
- W2371141275 title "Effects of Tea Polyphenol EGCG on the Metabolism of Brown Adipose Tissue in Mice" @default.
- W2371141275 hasPublicationYear "2014" @default.
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