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- W2371148413 abstract "Objective To study the inhibitory effects of valproic acid(VPA) on human ovarian cancer cell line SKOV3 in nude mice.Methods Human ovarian cancer line SKOV3 model transplanted subcutaneously in nude mice were established and divided into 4 groups:control,VPA,diamminedichloroplatinum(DDP) and VPA+DDP groups,6 in each group to observe and record the growth of nude mice and their transplanted tumors to draw tumor growth curve and calculate volume and inhibition rate.Flowcytometry(FCM) was used to assess apoptosis in the tissues of tumor,liver and brain,cell cycle phase,c-myc protein expression,CA-125 content and human telomerase reverse transcriptase(hTERT).Results VPA obviously inhibited the growth of tumor,induced cell cycle G0/G1 arrest and the apoptosis of carcinoma cell,suppressed c-myc expression and reduced CA-125 and hTERT contents,but did not induce obvious damage in liver and brain,had enhanced inhibition on tumor with DDP.Conclusions VPA could inhibit the growth of ovarian cancer by inducing the apoptosis and differentiation of tumor cells in nude mice,increase the sensitivity of human ovarian cancer cell line SKOV3 to DDP in vivo." @default.
- W2371148413 created "2016-06-24" @default.
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- W2371148413 date "2008-01-01" @default.
- W2371148413 modified "2023-09-25" @default.
- W2371148413 title "Study on inhibitory effects of VPA on human ovarian cancer cell line SKOV3 in nude mice" @default.
- W2371148413 hasPublicationYear "2008" @default.
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