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- W2371204412 abstract "The antitumor effect of 6-fluoro-thiochromene[4,3-c]pyrazoline(Ja)in vivo was studied in mice with subcutaneous inoculation of the tumor cells.Through observing the inhibitory effects in vivo of Ja on H22 and S180 tumors,tumor growth inhibition rates and the rates of survival prolongation were calculated,and contrasting with positive control drug DDP.The results showed the compound inhibited the growth of implanted solid tumor H22 and prolonged live time implanted ascitic tumor S180 of mice in a dose-dependent manner.At the dose of 1,2,and 4 mg/(kg·d)(i.p.) and 5,10,and 20 mg/(kg·d)(i.g.),the inhibition rates of Ja on H22 tumor in 3 repeated experiments were 13.93%,37.49%,47.45% and 31.53%,43.77%,50.73% respectively,and the rates of survival prolongation of the tumor-bearing mice were 30.4%,64.7% and 88.2% at the dose of 5,10,and 20 mg/(kg·d)(i.g.),respectively.The compound which possesses obvious antitumor activity in vivo deserves further research on its antitumor-mechanism." @default.
- W2371204412 created "2016-06-24" @default.
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- W2371204412 date "2009-01-01" @default.
- W2371204412 modified "2023-09-23" @default.
- W2371204412 title "Antitumor Activity of 6-Fluoro-thiochromene[4,3-c]pyrazoline in Vivo" @default.
- W2371204412 hasPublicationYear "2009" @default.
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