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- W2371206025 abstract "Objective To study the preventive effect of Tetrahydroxystilbene glucoside(TSG)on experimental diabetic nephropathy in rats. Methods Diabetes mellitus was induced in male Sprague-Dawley rats by intraperitoneal injection of streptozotocin(60mg/kg).The activity of superoxide dismutase(SOD) and the levels of malondialdehyde(MDA),nitric oxide(NO) in renal tissue and serum were assayed by chromatometry.The pathological changes of renal tissue were observated by light microcopy. Results TSG could significantly decrease the content of MDA,increase the levels of SOD and NO in serum and renal tissue of diabetic rats induced by high-fat diet,and the effects were dose-dependent.Histological observation showed that TSG could also remarkably alleviate the pathological injury of diabetic nephropathy in rats. Conclusion TSG has protective effect on the experimental diabetic rats induced by high-fat diet and the mechanism may be related to its antioxidative capacity." @default.
- W2371206025 created "2016-06-24" @default.
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- W2371206025 date "2011-01-01" @default.
- W2371206025 modified "2023-09-23" @default.
- W2371206025 title "Protective Effect of Tetrahydroxystilbene Glucoside on Experimental Diabetic Nephropathy in Rats" @default.
- W2371206025 hasPublicationYear "2011" @default.
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