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- W2371208495 abstract "Aim: To study the effect of the title drugs on the serum FSH, LH andtestosterone (T) levels in Chinese men in a contraceptive trial. Methods:Sixteen male volunteers were administered Chinese-made implant (tworods, each containing 75 mg of levonorgestrel, LNG) plus testosterone un-decanoate (TU) (250 mg, i.m. monthly for3 months). FSH, LH and Tlevels were determined with RIA. Results: The serum FSH and LH lev-els declined after the insertion of implants. They declined further after the1st TU injection and one week later, both FSH and LH levels reached thelowest levels, after which, they rose slightly. The profiles of serum LH andFSH levels after the 2nd and 3rd TU injection were similar to that followingthe 1st TU injection. After insertion of the implants, the serum T levels alsodeclined. However, after the 1st dose of TU, the T levels increased, oneweek later they reached the peak level, and then declined again. The pro-files of serum T levels after the 2nd and 3rd TU injection were also similarto that following the 1st injection. Conclusion: LNG and TU could pro-duce synergic feedback inhibition on the secretion of gonadotropins and T,while the injection of TU would maintain a physiological T level in men.Therefore the regimen of implants plus TU seems to be a promising combi-nation for male contraception." @default.
- W2371208495 created "2016-06-24" @default.
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- W2371208495 date "2001-01-01" @default.
- W2371208495 modified "2023-09-27" @default.
- W2371208495 title "Effect of combined use of Chinese-made implants and testosterone undecanoate on pituary-gonadal axis in Chinese men" @default.
- W2371208495 hasPublicationYear "2001" @default.
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