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- W2371240474 abstract "Objective To find the optimally safe and effective dose of live attenuated anthrax vaccine in mice for the further study on the safety and efficacy of multiple vaccines simultaneously administered. Methods Mice were randomized into 4 dose groups, and were injected subcutaneously with different doses of anthrax vaccine. Blood was collected from tail veins every week for detecting the specific IgG to PA and spore by indirect ELISA. The mice were sacrificed at the twelfth week after inoculation. Body weight, immunological response, pathology indices, biochemical indices and spontaneous activity were monitored. Results IgG were induced in the mice inoculated with the vaccine at 1/5 and 1/10 human vaccine dose rapidly and were maintained at a high level even 12 weeks after inoculation. However, antibody titers of 1/20 and 1/40 human dose were relatively low. There was a significant difference among the antibody titers in different groups. Conclusions 1/10 human dose is preferred as the optimal choice for the safety and the efficacy. The present work provides a basis for further research into multiple vaccines simultaneously inoculated and development of the anthrax vaccine in mice." @default.
- W2371240474 created "2016-06-24" @default.
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- W2371240474 date "2009-01-01" @default.
- W2371240474 modified "2023-09-28" @default.
- W2371240474 title "Screening of the optimal dose for immunization to live attenuated anthrax vaccine in mice" @default.
- W2371240474 hasPublicationYear "2009" @default.
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