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- W2371241132 abstract "Aim To investigate the effects of 4-aminopyridine (4-AP),K+ channel blocker, on the gastrointestinal function of murine. Methods Charcoal suspension was used to detect the effects of 4-AP on gastrointestinal motility of mice in vivo, contraction of isolated fundus longitudinal strips and duodenum of rats were studied in vitro,gastric acid secretion was measured by Gastric Secretion Test. Results 4-AP(5 mg·kg -1,ig)inhibited the gastrointestinal motility of mice. 4-AP(5 mmol·L -1) increased the maximum contractive force and minimum relaxation force, decreased the amplitude and frequency of the isolated duodenum peristaltic contraction. 4-AP(2.5 mg·kg -1,ip) significantly enhanced gastric acid secretion of rats. Conclusion 4-AP inhibited gastrointestinal motility and enhanced gastric acid secretion in murine." @default.
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- W2371241132 date "2005-01-01" @default.
- W2371241132 modified "2023-09-23" @default.
- W2371241132 title "Effects of 4-aminopyridine on the gastrointestinal function of murine" @default.
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